Dr. Shantanu Joshi, assistant professor in the Department of Neurology at UCLA, has discovered structural and functional brain abnormalities among bipolar patients by utilizing MRI and fMRI imaging. In terms of functional abnormalities, participants with bipolar disorder showed reduced activation in the following brain regions: inferior frontal cortex, anterior cingulate cortex, and superior frontal gyrus. After this fMRI data was collected, MRI imaging data indicated a reduction in cortical thickness in the same brain regions. Joshi hopes that his research has implications for finding the biomarkers for bipolar disorder. This research was funded, in part, by the National Institute of Mental Health.
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