Archive Tag: Discovery Neuroscience

A mini brain organoid, with layered neural tissue and different groups of neural stem cells (in blue, red and magenta) giving rise to neurons (green).
UCLA Broad Stem Cell Research Center/Cell Reports

UCLA researchers have found a way to create simplified human brain tissue using stem cells, which provides a more convenient method to study the brain and neurological diseases. The researchers call these tissues “mini brain organoids”, which are similar to the human brain in several ways; for example, the anatomy of the brain organoids resembles that of the human cortex, Read more

Discovery Neuroscience Demonstration Project: Using tools to reveal the role of specific brain regions in depression

Studies looking at depression in humans and models of depression in animals show that depression involves changes in a part of the brain called the striatum. The striatum controls how we process rewards and attribute value to our experiences, while also regulating our goal-directed and habitual actions. Read more

Discovery Neuroscience Demonstration Project: Astrocytes may have a big impact

Depression—the most common cause of disability in the world— places serious demands on health services and is a major contributor to suicide.  Yet our ability to develop new, more effective treatments continues to hit obstacles largely due to a lack of understanding of the cellular and molecular basis of the causes. One exciting opportunity arises from recently acquired knowledge about the function of astrocytes—a cell type Read more

Dr. Peyman Golshani, Daniel Aharoni and UCLA colleagues are making detailed instructions for building the device available to other scientists around the world.
Leigh Hopper/UCLA Health

UCLA researchers score a $8.3 million grant from the National Science Foundations because they have made it possible to literally see inside an animal’s brain with the invention of a tiny microscope. This project has been established through a collaboration among professors Peyman Golshani, Tad Blair, Jason Cong and Alcino Silva, Sotiris Masmanidis and Daniel Aharoni, all of UCLA; and Alipasha Vaziri, a professor at Read more