The UCLA Depression Grand Challenge (DGC) has come a long way since it’s initial annoucement last October 2015. The initiative is tackling depression in an unprecedented manner with an aim to better understand and treat this devastating disease. One year later, the DGC has begun a series of studies and set a program in place that will screen and treat UCLA student and staff for depression. At the heart of the UCLA initiative, is the 10-year “100K Study” that will monitor 100,000 people with the goals of identifying the genetic and environmental causes of depression. The study is the largest of its kind to date and will screen for depression by examining participants’ genetics and assessing symptoms through remote monitoring.